The combined effect of eight-week resveratrol supplementation and interval training on some regulatory and executive factors of hepatocyte apoptosis in male rats with diabetes

Background and aims: The aim of this study was to investigate the combined effect interval training resveratrol consumption on regulatory executive factors hepatocyte apoptosis in male rats with diabetes. Methods: Frothy-two Wistar were randomly divided into healthy control, diabetic, saline supplement, intermittent exercise, resveratrol+intermittent exercise groups. program consisted 8 weeks an intensity 50%-70% maximum oxygen consumption. Resveratrol injected two groups supplement resveratrol+supplement at a dose 20 mg. Results: concentrations caspase-3 BAX diabetic significantly higher than control (P=0.001). On other hand, Bcl-2 (B-cell lymphoma 2) levels lower concentration BAX/Bcl-2 ratio compared (P=0.001) training, administration alone, or especially caused significant decrease (P=0.001), increase mean diabetes Conclusion: eight-week supplementation decreased markers, while it increased type 2